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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43377
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
30±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43377
Synonyms:
2-[ethyl-[(4-keto-1H-quinazolin-2-yl)methyl]amino]-N-(4-morpholinophenyl)acetamide | 2-[ethyl-[(4-oxidanylidene-1H-quinazolin-2-yl)methyl]amino]-N-(4-morpholin-4-ylphenyl)ethanamide | 2-[ethyl-[(4-oxo-1H-quinazolin-2-yl)methyl]amino]-N-(4-morpholin-4-ylphenyl)acetamide | 2-[ethyl-[(4-oxo-1H-quinazolin-2-yl)methyl]amino]-N-[4-(4-morpholinyl)phenyl]acetamide | MLS000568833 | SMR000154836 | cid_2107414
Type:
Small organic molecule
Emp. Form.:
C23H27N5O3
Mol. Mass.:
421.4922
SMILES:
CCN(CC(=O)Nc1ccc(cc1)N1CCOCC1)Cc1nc2ccccc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: