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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43380
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
149430±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43380
Synonyms:
2-[(4-acetamidophenyl)sulfonyl-methyl-amino]acetic acid (2-indolin-1-yl-2-keto-ethyl) ester | 2-[(4-acetamidophenyl)sulfonyl-methylamino]acetic acid [2-(2,3-dihydroindol-1-yl)-2-oxoethyl] ester | MLS000570308 | SMR000150309 | [2-(2,3-dihydroindol-1-yl)-2-oxidanylidene-ethyl] 2-[(4-acetamidophenyl)sulfonyl-methyl-amino]ethanoate | [2-(2,3-dihydroindol-1-yl)-2-oxoethyl] 2-[(4-acetamidophenyl)sulfonyl-methylamino]acetate | cid_2475617
Type:
Small organic molecule
Emp. Form.:
C21H23N3O6S
Mol. Mass.:
445.489
SMILES:
CN(CC(=O)OCC(=O)N1CCc2ccccc12)S(=O)(=O)c1ccc(NC(C)=O)cc1
Structure:
Search PDB for entries with ligand similarity: