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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43437
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
10±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43437
Synonyms:
(6-methyl-3-nitro-2-oxidanylidene-1H-pyridin-4-yl) benzoate | (6-methyl-3-nitro-2-oxo-1H-pyridin-4-yl) benzoate | MLS000680115 | SMR000324732 | benzoic acid (2-keto-6-methyl-3-nitro-1H-pyridin-4-yl) ester | benzoic acid (6-methyl-3-nitro-2-oxo-1H-pyridin-4-yl) ester | cid_7150639
Type:
Small organic molecule
Emp. Form.:
C13H10N2O5
Mol. Mass.:
274.2289
SMILES:
Cc1cc(OC(=O)c2ccccc2)c([N+]([O-])=O)c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: