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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43498
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
3060±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43498
Synonyms:
1,1-bis(oxidanylidene)-2-(phenylmethyl)-3,4-dihydro-1,2-benzothiazepin-5-one | 1,1-dioxo-2-(phenylmethyl)-3,4-dihydro-1,2-benzothiazepin-5-one | 2-benzyl-1,1-diketo-3,4-dihydro-1,2-benzothiazepin-5-one | 2-benzyl-1,1-dioxo-3,4-dihydro-1,2-benzothiazepin-5-one | MLS000879339 | SMR000465155 | cid_16060207
Type:
Small organic molecule
Emp. Form.:
C16H15NO3S
Mol. Mass.:
301.36
SMILES:
O=C1CCN(Cc2ccccc2)S(=O)(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: