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Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM43511
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT1 inhibition
IC50
6371±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT1 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM43511
Synonyms:
2-[[(5-methyl-2-phenyl-3-pyrazolyl)amino]methylidene]propanedioic acid diethyl ester | 2-[[(5-methyl-2-phenyl-pyrazol-3-yl)amino]methylene]malonic acid diethyl ester | MLS000520937 | SMR000131346 | cid_4073731 | diethyl 2-[[(5-methyl-2-phenyl-pyrazol-3-yl)amino]methylidene]propanedioate | diethyl 2-[[(5-methyl-2-phenylpyrazol-3-yl)amino]methylidene]propanedioate
Type:
Small organic molecule
Emp. Form.:
C18H21N3O4
Mol. Mass.:
343.377
SMILES:
CCOC(=O)C(C=Nc1cc(C)nn1-c1ccccc1)C(=O)OCC |w:7.7|
Structure:
Search PDB for entries with ligand similarity: