Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43613
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 activation
IC50
5903±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 activation PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43613
Synonyms:
2-amino-4-(4-chlorophenyl)-6-methyl-3-pyridinecarbonitrile | 2-amino-4-(4-chlorophenyl)-6-methyl-nicotinonitrile | 2-amino-4-(4-chlorophenyl)-6-methylnicotinonitrile | 2-amino-4-(4-chlorophenyl)-6-methylpyridine-3-carbonitrile | 2-azanyl-4-(4-chlorophenyl)-6-methyl-pyridine-3-carbonitrile | MLS000533080 | SMR000140518 | cid_743778
Type:
Small organic molecule
Emp. Form.:
C13H10ClN3
Mol. Mass.:
243.692
SMILES:
Cc1cc(-c2ccc(Cl)cc2)c(C#N)c(N)n1
Structure:
Search PDB for entries with ligand similarity: