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Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43622
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 activation
IC50
4817±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 activation PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43622
Synonyms:
6-[1-(2-chloro-6-fluoro-phenyl)-1,3,4,9-tetrahydro-beta-carboline-2-carbonyl]-2-methyl-4,5-dihydropyridazin-3-one | 6-[1-(2-chloro-6-fluorophenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carbonyl]-2-methyl-4,5-dihydropyridazin-3-one | 6-[[1-(2-chloranyl-6-fluoranyl-phenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]carbonyl]-2-methyl-4,5-dihydropyridazin-3-one | 6-[[1-(2-chloro-6-fluorophenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-oxomethyl]-2-methyl-4,5-dihydropyridazin-3-one | 6-{[1-(2-chloro-6-fluorophenyl)-1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl]carbonyl}-2-methyl-4,5-dihydropyridazin-3(2H)-one | MLS000735307 | SMR000319297 | cid_16187319
Type:
Small organic molecule
Emp. Form.:
C23H20ClFN4O2
Mol. Mass.:
438.882
SMILES:
CN1N=C(CCC1=O)C(=O)N1CCc2c([nH]c3ccccc23)C1c1c(F)cccc1Cl |c:2|
Structure:
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