Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43636
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 activation
IC50
2437±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 activation PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43636
Synonyms:
6-[1-(2-fluoro-4-methoxy-phenyl)-1,3,4,9-tetrahydro-beta-carboline-2-carbonyl]-2-methyl-pyridazin-3-one | 6-[1-(2-fluoro-4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carbonyl]-2-methylpyridazin-3-one | 6-[[1-(2-fluoranyl-4-methoxy-phenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]carbonyl]-2-methyl-pyridazin-3-one | 6-[[1-(2-fluoro-4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-oxomethyl]-2-methyl-3-pyridazinone | 6-{[1-(2-fluoro-4-methoxyphenyl)-1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl]carbonyl}-2-methylpyridazin-3(2H)-one | MLS000733516 | SMR000316865 | cid_16191401
Type:
Small organic molecule
Emp. Form.:
C24H21FN4O3
Mol. Mass.:
432.4469
SMILES:
COc1ccc(C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccc(=O)n(C)n2)c(F)c1
Structure:
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