Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43646
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 activation
IC50
3559±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 activation PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43646
Synonyms:
1-(4-methyl-1-piperazinyl)-2-[2-nitro-4-(trifluoromethyl)anilino]ethanone | 1-(4-methylpiperazin-1-yl)-2-[2-nitro-4-(trifluoromethyl)anilino]ethanone | 1-(4-methylpiperazin-1-yl)-2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]ethanone | 1-(4-methylpiperazino)-2-[2-nitro-4-(trifluoromethyl)anilino]ethanone | MLS000663978 | N-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-nitro-4-(trifluoromethyl)aniline | SMR000270601 | cid_2915848
Type:
Small organic molecule
Emp. Form.:
C14H17F3N4O3
Mol. Mass.:
346.305
SMILES:
CN1CCN(CC1)C(=O)CNc1ccc(cc1[N+]([O-])=O)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: