Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43647
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 activation
IC50
>229±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 activation PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43647
Synonyms:
(4E)-4-(1H-indol-2-ylmethylene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one | 4-[(Z)-2-indolylidenemethyl]-5-methyl-2-phenyl-1H-pyrazol-3-one | 4-[(Z)-indol-2-ylidenemethyl]-5-methyl-2-phenyl-1H-pyrazol-3-one | 4-[(Z)-indol-2-ylidenemethyl]-5-methyl-2-phenyl-3-pyrazolin-3-one | MLS000724469 | SMR000306063 | cid_6614727
Type:
Small organic molecule
Emp. Form.:
C19H15N3O
Mol. Mass.:
301.3419
SMILES:
Cc1[nH]n(-c2ccccc2)c(=O)c1C=C1C=c2ccccc2=N1 |w:13.14,c:24,t:17|
Structure:
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