Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM43800
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay
EC50
20000±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM43800
Synonyms:
MLS-0096316.0001 | N'-[2-(4-methoxyphenoxy)-1-oxoethyl]-2-pyridinecarbohydrazide | N'-[2-(4-methoxyphenoxy)acetyl]picolinohydrazide | N'-[2-(4-methoxyphenoxy)acetyl]pyridine-2-carbohydrazide | N'-[2-(4-methoxyphenoxy)ethanoyl]pyridine-2-carbohydrazide | cid_774167
Type:
Small organic molecule
Emp. Form.:
C15H15N3O4
Mol. Mass.:
301.2973
SMILES:
COc1ccc(OCC(=O)NNC(=O)c2ccccn2)cc1
Structure:
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