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Target
Leucine--tRNA ligase
Ligand
BDBM43824
Substrate
n/a
Meas. Tech.
Binding Asssay
pH
7.5±0
Temperature
273.15±n/a K
Kd
1.300e+6± 1.00e+5 nM
Citation
 Llano-Sotelo, B; Azucena, EF; Kotra, LP; Mobashery, S; Chow, CS Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. Chem Biol 9:455-63 (2002) [PubMed]  Article 
Target
Name:
Leucine--tRNA ligase
Synonyms:
Aminoacyl-tRNA synthetase
Type:
PROTEIN
Mol. Mass.:
101024.31
Organism:
Thermus thermophilus
Description:
Q7SIE4
Residue:
878
Sequence:
MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVMFPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYDWDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCPKCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYAERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKEVRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEVLAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERIPIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKKVIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRKVIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCEACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFYETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLPFDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLGMVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTRIRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSKSKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEGVQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRELYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRKDRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLFEAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLEVARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVVRG
  
Inhibitor
Name:
BDBM43824
Synonyms:
Aminoglycosides, 2 | MLS000533892 | N-[(E)-N''''-(1,3-benzothiazol-2-yl)amidino]-3-methyl-butyramide | N-[(E)-N''''-(1,3-benzothiazol-2-yl)carbamimidoyl]-3-methyl-butanamide | N-[(E)-N''''-(1,3-benzothiazol-2-yl)carbamimidoyl]-3-methylbutanamide | N-[(E)-N''-(1,3-benzothiazol-2-yl)amidino]-3-methyl-butyramide | N-[(E)-N'-(1,3-benzothiazol-2-yl)amidino]-3-methyl-butyramide | N-[(E)-amino(1,3-benzothiazol-2-ylimino)methyl]-3-methylbutanamide | N-[amino(1,3-benzothiazol-2-ylamino)methylene]-3-methylbutanamide | SMR000141329 | cid_9551574
Type:
Small organic molecule
Emp. Form.:
C13H16N4OS
Mol. Mass.:
276.357
SMILES:
CC(C)CC(=O)NC(N)=Nc1nc2ccccc2s1 |w:9.9|
Structure:
Search PDB for entries with ligand similarity: