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Target
Leucine--tRNA ligase
Ligand
BDBM43825
Substrate
n/a
Meas. Tech.
Binding Asssay
pH
7.5±0
Temperature
273.15±n/a K
Kd
2.000e+6± 1.00e+5 nM
Citation
 Llano-Sotelo, B; Azucena, EF; Kotra, LP; Mobashery, S; Chow, CS Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. Chem Biol 9:455-63 (2002) [PubMed]  Article 
Target
Name:
Leucine--tRNA ligase
Synonyms:
Aminoacyl-tRNA synthetase
Type:
PROTEIN
Mol. Mass.:
101024.31
Organism:
Thermus thermophilus
Description:
Q7SIE4
Residue:
878
Sequence:
MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVMFPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYDWDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCPKCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYAERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKEVRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEVLAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERIPIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKKVIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRKVIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCEACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFYETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLPFDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLGMVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTRIRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSKSKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEGVQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRELYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRKDRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLFEAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLEVARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVVRG
  
Inhibitor
Name:
BDBM43825
Synonyms:
(Z)-3-(3-chloro-2-methyl-anilino)-2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]acrylic acid methyl ester | (Z)-3-(3-chloro-2-methylanilino)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2-propenoic acid methyl ester | Aminoglycosides, 3 | MLS000540882 | SMR000125940 | cid_6511833 | methyl (Z)-3-(3-chloro-2-methylanilino)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2-propenoate | methyl (Z)-3-(3-chloro-2-methylanilino)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]prop-2-enoate | methyl (Z)-3-[(3-chloranyl-2-methyl-phenyl)amino]-2-[3-chloranyl-5-(trifluoromethyl)pyridin-2-yl]prop-2-enoate
Type:
Small organic molecule
Emp. Form.:
C17H13Cl2F3N2O2
Mol. Mass.:
405.199
SMILES:
COC(=O)C(C=Nc1cccc(Cl)c1C)c1ncc(cc1Cl)C(F)(F)F |w:6.6|
Structure:
Search PDB for entries with ligand similarity: