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Target
Leucine--tRNA ligase
Ligand
BDBM43827
Substrate
n/a
Meas. Tech.
Binding Asssay
pH
7.5±0
Temperature
273.15±n/a K
Kd
1.700e+6± 1.00e+5 nM
Citation
 Llano-Sotelo, B; Azucena, EF; Kotra, LP; Mobashery, S; Chow, CS Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. Chem Biol 9:455-63 (2002) [PubMed]  Article 
Target
Name:
Leucine--tRNA ligase
Synonyms:
Aminoacyl-tRNA synthetase
Type:
PROTEIN
Mol. Mass.:
101024.31
Organism:
Thermus thermophilus
Description:
Q7SIE4
Residue:
878
Sequence:
MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVMFPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYDWDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCPKCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYAERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKEVRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEVLAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERIPIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKKVIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRKVIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCEACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFYETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLPFDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLGMVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTRIRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSKSKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEGVQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRELYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRKDRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLFEAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLEVARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVVRG
  
Inhibitor
Name:
BDBM43827
Synonyms:
(E)-3-(1-benzyl-3-phenyl-pyrazol-4-yl)acrylic acid | (E)-3-(1-benzyl-3-phenylpyrazol-4-yl)prop-2-enoic acid | (E)-3-[3-phenyl-1-(phenylmethyl)-4-pyrazolyl]-2-propenoic acid | (E)-3-[3-phenyl-1-(phenylmethyl)pyrazol-4-yl]prop-2-enoic acid | Aminoglycosides, 4 | MLS000567315 | SMR000154054 | cid_2565969
Type:
Small organic molecule
Emp. Form.:
C19H16N2O2
Mol. Mass.:
304.3425
SMILES:
OC(=O)\C=C\c1cn(Cc2ccccc2)nc1-c1ccccc1
Structure:
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