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Target
Leucine--tRNA ligase
Ligand
BDBM43826
Substrate
n/a
Meas. Tech.
Binding Asssay
pH
7.5±0
Temperature
273.15±n/a K
Kd
6.00e+5± 2.0e+4 nM
Citation
 Llano-Sotelo, B; Azucena, EF; Kotra, LP; Mobashery, S; Chow, CS Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. Chem Biol 9:455-63 (2002) [PubMed]  Article 
Target
Name:
Leucine--tRNA ligase
Synonyms:
Aminoacyl-tRNA synthetase
Type:
PROTEIN
Mol. Mass.:
101024.31
Organism:
Thermus thermophilus
Description:
Q7SIE4
Residue:
878
Sequence:
MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVMFPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYDWDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCPKCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYAERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKEVRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEVLAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERIPIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKKVIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRKVIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCEACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFYETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLPFDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLGMVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTRIRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSKSKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEGVQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRELYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRKDRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLFEAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLEVARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVVRG
  
Inhibitor
Name:
BDBM43826
Synonyms:
2-[5-(diethylsulfamoyl)-1-(4-methoxyphenyl)benzimidazol-2-yl]sulfanylpropanamide | 2-[[5-(diethylsulfamoyl)-1-(4-methoxyphenyl)-2-benzimidazolyl]thio]propanamide | 2-[[5-(diethylsulfamoyl)-1-(4-methoxyphenyl)benzimidazol-2-yl]thio]propionamide | Aminoglycosides, 5 | MLS000568202 | SMR000154533 | cid_4884909
Type:
Small organic molecule
Emp. Form.:
C21H26N4O4S2
Mol. Mass.:
462.586
SMILES:
CCN(CC)S(=O)(=O)c1ccc2n(c(SC(C)C(N)=O)nc2c1)-c1ccc(OC)cc1
Structure:
Search PDB for entries with ligand similarity: