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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM44401
Substrate
n/a
Meas. Tech.
TNAP luminescent HTS assay
IC50
1730±270 nM
Citation
 PubChem, PC TNAP luminescent HTS assay PubChem Bioassay (2008)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM44401
Synonyms:
(E)-3-amino-2-[2-[[5-(2-bromophenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile | (E)-3-amino-2-[2-[[5-(2-bromophenyl)-1H-1,2,4-triazol-3-yl]thio]-1-oxoethyl]-2-butenenitrile | (E)-3-amino-2-[2-[[5-(2-bromophenyl)-1H-1,2,4-triazol-3-yl]thio]acetyl]but-2-enenitrile | (E)-3-azanyl-2-[2-[[5-(2-bromophenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]ethanoyl]but-2-enenitrile | MLS000056327 | SMR000068598 | cid_5742579
Type:
Small organic molecule
Emp. Form.:
C14H12BrN5OS
Mol. Mass.:
378.247
SMILES:
CC(=N)C(C#N)C(=O)CSc1nnc([nH]1)-c1ccccc1Br
Structure:
Search PDB for entries with ligand similarity: