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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM44421
Substrate
n/a
Meas. Tech.
TNAP luminescent HTS assay
IC50
>100000±0 nM
Citation
 PubChem, PC TNAP luminescent HTS assay PubChem Bioassay (2008)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM44421
Synonyms:
MLS000103608 | N-(1,3-dimethyl-2,6-dioxo-4-pyrimidinyl)-3,3-dimethylbutanamide | N-(1,3-dimethyl-2,6-dioxopyrimidin-4-yl)-3,3-dimethylbutanamide | N-(2,6-diketo-1,3-dimethyl-pyrimidin-4-yl)-3,3-dimethyl-butyramide | N-[1,3-dimethyl-2,6-bis(oxidanylidene)pyrimidin-4-yl]-3,3-dimethyl-butanamide | SMR000018880 | cid_2148506
Type:
Small organic molecule
Emp. Form.:
C12H19N3O3
Mol. Mass.:
253.2976
SMILES:
Cn1c(NC(=O)CC(C)(C)C)cc(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity: