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Target
Bcl-2-like protein 10 [11-204]
Ligand
BDBM46303
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein.
EC50
12200±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-like protein 10 [11-204]
Synonyms:
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH). | B2L10_HUMAN | BCL-B | BCL2L10 | BCLB | BOO | DIVA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21981.77
Organism:
Homo sapiens (Human)
Description:
gi_23396469
Residue:
194
Sequence:
MADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
  
Inhibitor
Name:
BDBM46303
Synonyms:
3-(2-methoxybenzyl)-5-[1-(4-methylbenzoyl)piperidin-4-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol | 3-[(2-methoxyphenyl)methyl]-5-[1-(4-methylbenzoyl)piperidin-4-yl]-2H-triazolo[4,5-d]pyrimidin-7-one | 3-[(2-methoxyphenyl)methyl]-5-[1-(4-methylphenyl)carbonylpiperidin-4-yl]-2H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one | 3-[(2-methoxyphenyl)methyl]-5-[1-[(4-methylphenyl)-oxomethyl]-4-piperidinyl]-2H-triazolo[4,5-d]pyrimidin-7-one | 3-o-anisyl-5-(1-p-toluoyl-4-piperidyl)-2H-triazolo[4,5-d]pyrimidin-7-one | MLS000094263 | SMR000029853 | cid_3237110
Type:
Small organic molecule
Emp. Form.:
C25H26N6O3
Mol. Mass.:
458.5123
SMILES:
COc1ccccc1Cn1nnc2c1nc([nH]c2=O)C1CCN(CC1)C(=O)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: