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Target
Bcl-2-like protein 10 [11-204]
Ligand
BDBM46304
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein.
EC50
17380±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-like protein 10 [11-204]
Synonyms:
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH). | B2L10_HUMAN | BCL-B | BCL2L10 | BCLB | BOO | DIVA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21981.77
Organism:
Homo sapiens (Human)
Description:
gi_23396469
Residue:
194
Sequence:
MADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
  
Inhibitor
Name:
BDBM46304
Synonyms:
MLS000521783 | N-(3,5-dimethylphenyl)-1,3-dimethyl-2,4-bis(oxidanylidene)quinazoline-6-sulfonamide | N-(3,5-dimethylphenyl)-1,3-dimethyl-2,4-dioxo-6-quinazolinesulfonamide | N-(3,5-dimethylphenyl)-1,3-dimethyl-2,4-dioxoquinazoline-6-sulfonamide | N-(3,5-dimethylphenyl)-2,4-diketo-1,3-dimethyl-quinazoline-6-sulfonamide | SMR000132191 | cid_4109389
Type:
Small organic molecule
Emp. Form.:
C18H19N3O4S
Mol. Mass.:
373.426
SMILES:
Cc1cc(C)cc(NS(=O)(=O)c2ccc3n(C)c(=O)n(C)c(=O)c3c2)c1
Structure:
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