Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM46314
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
922.6±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM46314
Synonyms:
2-(4-fluoro-N-[2-[(8-methoxy-5H-[1,2,4]triazin[5,6-b]indol-3-yl)thio]acetyl]anilino)acetic acid ethyl ester | 2-(4-fluoro-N-[2-[(8-methoxy-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]-1-oxoethyl]anilino)acetic acid ethyl ester | MLS000068843 | SMR000002091 | cid_5770453 | ethyl 2-(4-fluoro-N-[2-[(8-methoxy-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetyl]anilino)acetate | ethyl 2-[(4-fluorophenyl)-[2-[(8-methoxy-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethanoyl]amino]ethanoate | {(4-Fluoro-phenyl)-[2-(8-methoxy-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-acetyl]-amino}-acetic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C22H20FN5O4S
Mol. Mass.:
469.489
SMILES:
CCOC(=O)CN(C(=O)CSc1nnc2c(n1)[nH]c1ccc(OC)cc21)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: