Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM46317
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
9207±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM46317
Synonyms:
7-(2-furanylmethylamino)-2,3-dimethyl-4-thieno[1,2]pyrimido[4,5-b]pyridazinone | 7-(2-furfurylamino)-2,3-dimethyl-thieno[1,2]pyrimido[4,5-b]pyridazin-4-one | 7-(furan-2-ylmethylamino)-2,3-dimethyl-thieno[1,2]pyrimido[4,5-b]pyridazin-4-one | 7-(furan-2-ylmethylamino)-2,3-dimethylthieno[1,2]pyrimido[4,5-b]pyridazin-4-one | MLS000568513 | SMR000154644 | cid_705876
Type:
Small organic molecule
Emp. Form.:
C16H14N4O2S
Mol. Mass.:
326.373
SMILES:
Cc1sc2nc3ccc(NCc4ccco4)nn3c(=O)c2c1C
Structure:
Search PDB for entries with ligand similarity: