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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM46318
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
1666±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM46318
Synonyms:
2-amino-4-methyl-N'-(3,4,5-trimethoxybenzylidene)-1,3-thiazole-5-carbohydrazide | 2-amino-4-methyl-N-[(3,4,5-trimethoxybenzylidene)amino]thiazole-5-carboxamide | 2-amino-4-methyl-N-[(3,4,5-trimethoxyphenyl)methylideneamino]-1,3-thiazole-5-carboxamide | 2-amino-4-methyl-N-[(3,4,5-trimethoxyphenyl)methylideneamino]-5-thiazolecarboxamide | 2-azanyl-4-methyl-N-[(3,4,5-trimethoxyphenyl)methylideneamino]-1,3-thiazole-5-carboxamide | MLS000545601 | SMR000162971 | cid_1036441
Type:
Small organic molecule
Emp. Form.:
C15H18N4O4S
Mol. Mass.:
350.393
SMILES:
COc1cc(C=NNC(=O)c2sc(N)nc2C)cc(OC)c1OC |w:6.6|
Structure:
Search PDB for entries with ligand similarity: