Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM46333
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
28370±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM46333
Synonyms:
5-amino-3-(cyanomethyl)-1-(3-methylphenyl)-4-pyrazolecarbonitrile | 5-amino-3-(cyanomethyl)-1-(3-methylphenyl)pyrazole-4-carbonitrile | 5-amino-3-(cyanomethyl)-1-(m-tolyl)pyrazole-4-carbonitrile | 5-azanyl-3-(cyanomethyl)-1-(3-methylphenyl)pyrazole-4-carbonitrile | MLS000878028 | SMR000376957 | cid_2444719
Type:
Small organic molecule
Emp. Form.:
C13H11N5
Mol. Mass.:
237.2599
SMILES:
Cc1cccc(c1)-n1nc(CC#N)c(C#N)c1N
Structure:
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