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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43232
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
5903±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43232
Synonyms:
3-[2-[1-[4-(difluoromethoxy)phenyl]-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl]-4-oxo-1-phthalazinecarboxylic acid | 3-[2-[1-[4-(difluoromethoxy)phenyl]-2,5-dimethyl-pyrrol-3-yl]-2-keto-ethyl]-4-keto-phthalazine-1-carboxylic acid | 3-[2-[1-[4-(difluoromethoxy)phenyl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl]-4-oxophthalazine-1-carboxylic acid | 3-[2-[1-[4-[bis(fluoranyl)methoxy]phenyl]-2,5-dimethyl-pyrrol-3-yl]-2-oxidanylidene-ethyl]-4-oxidanylidene-phthalazine-1-carboxylic acid | MLS001002331 | SMR000368851 | cid_2463084
Type:
Small organic molecule
Emp. Form.:
C24H19F2N3O5
Mol. Mass.:
467.4216
SMILES:
Cc1cc(C(=O)Cn2nc(C(O)=O)c3ccccc3c2=O)c(C)n1-c1ccc(OC(F)F)cc1
Structure:
Search PDB for entries with ligand similarity: