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Target
Regulator of G-protein signaling 8
Ligand
BDBM47725
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47725
Synonyms:
2-(2,5-diketo-4,4-dimethyl-imidazolidin-1-yl)-N-[4-(4-fluorophenyl)thiazol-2-yl]acetamide | 2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)-N-[4-(4-fluorophenyl)-2-thiazolyl]acetamide | 2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]acetamide | 2-[4,4-dimethyl-2,5-bis(oxidanylidene)imidazolidin-1-yl]-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]ethanamide | MLS000565157 | SMR000152370 | cid_2461966
Type:
Small organic molecule
Emp. Form.:
C16H15FN4O3S
Mol. Mass.:
362.379
SMILES:
CC1(C)NC(=O)N(CC(=O)Nc2nc(cs2)-c2ccc(F)cc2)C1=O
Structure:
Search PDB for entries with ligand similarity: