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Target
Regulator of G-protein signaling 8
Ligand
BDBM47729
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47729
Synonyms:
1-(3-Chloro-2-methyl-phenyl)-3-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-thiourea | 3-[1,3-bis(oxidanylidene)isoindol-2-yl]-N-[(3-chloranyl-2-methyl-phenyl)carbamothioyl]propanamide | MLS000557180 | N-[(3-chloro-2-methyl-phenyl)thiocarbamoyl]-3-phthalimido-propionamide | N-[(3-chloro-2-methylanilino)-sulfanylidenemethyl]-3-(1,3-dioxo-2-isoindolyl)propanamide | N-[(3-chloro-2-methylphenyl)carbamothioyl]-3-(1,3-dioxoisoindol-2-yl)propanamide | SMR000175477 | cid_1112400
Type:
Small organic molecule
Emp. Form.:
C19H16ClN3O3S
Mol. Mass.:
401.867
SMILES:
Cc1c(Cl)cccc1NC(=S)NC(=O)CCN1C(=O)c2ccccc2C1=O
Structure:
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