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Target
Regulator of G-protein signaling 8
Ligand
BDBM47742
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47742
Synonyms:
MLS000585978 | N-[1-(cyclopentylcarbamoyl)cyclohexyl]-6-keto-N-(2-thenyl)-1H-pyridine-3-carboxamide | N-[1-(cyclopentylcarbamoyl)cyclohexyl]-6-oxidanylidene-N-(thiophen-2-ylmethyl)-1H-pyridine-3-carboxamide | N-[1-(cyclopentylcarbamoyl)cyclohexyl]-6-oxo-N-(thiophen-2-ylmethyl)-1H-pyridine-3-carboxamide | N-[1-[(cyclopentylamino)-oxomethyl]cyclohexyl]-6-oxo-N-(thiophen-2-ylmethyl)-1H-pyridine-3-carboxamide | N-{1-[(cyclopentylamino)carbonyl]cyclohexyl}-6-oxo-N-(thien-2-ylmethyl)-1,6-dihydropyridine-3-carboxamide | SMR000207758 | cid_5200925
Type:
Small organic molecule
Emp. Form.:
C23H29N3O3S
Mol. Mass.:
427.56
SMILES:
O=C(NC1CCCC1)C1(CCCCC1)N(Cc1cccs1)C(=O)c1ccc(=O)[nH]c1
Structure:
Search PDB for entries with ligand similarity: