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Target
Regulator of G-protein signaling 8
Ligand
BDBM47772
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47772
Synonyms:
4-(4-bromophenyl)-3-[1-(4-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl]-1H-1,2,4-triazole-5-thione | 4-(4-bromophenyl)-3-[1-(4-chlorophenyl)-5-methyl-4-triazolyl]-1H-1,2,4-triazole-5-thione | 4-(4-bromophenyl)-3-[1-(4-chlorophenyl)-5-methyl-triazol-4-yl]-1H-1,2,4-triazole-5-thione | 4-(4-bromophenyl)-3-[1-(4-chlorophenyl)-5-methyltriazol-4-yl]-1H-1,2,4-triazole-5-thione | 4-(4-bromophenyl)-5-[1-(4-chlorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4H-1,2,4-triazole-3-thiol | MLS000699614 | SMR000229174 | cid_9511214
Type:
Small organic molecule
Emp. Form.:
C17H12BrClN6S
Mol. Mass.:
447.739
SMILES:
Cc1c(nnn1-c1ccc(Cl)cc1)-c1n[nH]c(=S)n1-c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: