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Target
D(1A) dopamine receptor
Ligand
BDBM36983
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.00314±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM36983
Synonyms:
(E)-3-amino-2-[2-[[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazol-2-yl]thio]acetyl]but-2-enenitrile | (E)-3-amino-2-[2-[[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile | (E)-3-amino-2-[2-[[5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-yl]thio]-1-oxoethyl]-2-butenenitrile | (E)-3-azanyl-2-[2-[[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanoyl]but-2-enenitrile | MLS000056051 | SMR000067128 | cid_5742495
Type:
Small organic molecule
Emp. Form.:
C15H13ClN4OS3
Mol. Mass.:
396.938
SMILES:
CC(=N)C(C#N)C(=O)CSc1nnc(SCc2ccc(Cl)cc2)s1
Structure:
Search PDB for entries with ligand similarity: