Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM49027
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.00223±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM49027
Synonyms:
3-methyl-5-[[1-oxo-2-(1,3,4-thiadiazol-2-ylthio)ethyl]amino]thiophene-2,4-dicarboxylic acid diethyl ester | 3-methyl-5-[[2-(1,3,4-thiadiazol-2-ylthio)acetyl]amino]thiophene-2,4-dicarboxylic acid diethyl ester | MLS000055102 | SMR000066735 | cid_2110226 | diethyl 3-methyl-5-[2-(1,3,4-thiadiazol-2-ylsulfanyl)ethanoylamino]thiophene-2,4-dicarboxylate | diethyl 3-methyl-5-[[2-(1,3,4-thiadiazol-2-ylsulfanyl)acetyl]amino]thiophene-2,4-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C15H17N3O5S3
Mol. Mass.:
415.508
SMILES:
CCOC(=O)c1sc(NC(=O)CSc2nncs2)c(C(=O)OCC)c1C
Structure:
Search PDB for entries with ligand similarity: