Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM49044
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.00475±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM49044
Synonyms:
1-(3-methoxypropyl)-5-oxo-2-[oxo(3-pyridinyl)methyl]imino-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester | 5-keto-1-(3-methoxypropyl)-2-nicotinoylimino-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylic acid ethyl ester | MLS000044286 | SMR000022068 | cid_2158293 | ethyl (2E)-1-(3-methoxypropyl)-5-oxo-2-[(pyridin-3-ylcarbonyl)imino]-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate | ethyl 1-(3-methoxypropyl)-5-oxidanylidene-2-pyridin-3-ylcarbonylimino-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate | ethyl 1-(3-methoxypropyl)-5-oxo-2-(pyridine-3-carbonylimino)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C24H23N5O5
Mol. Mass.:
461.4699
SMILES:
CCOC(=O)c1cc2c(nc3ccccn3c2=O)n(CCCOC)\c1=N\C(=O)c1cccnc1
Structure:
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