Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM48953
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.00778±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM48953
Synonyms:
4-[4-chloro-3-(phenylsulfamoyl)benzoyl]piperazine-1-carboxylic acid ethyl ester | 4-[[4-chloro-3-(phenylsulfamoyl)phenyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester | MLS000052632 | SMR000082213 | cid_2980124 | ethyl 4-[3-(anilinosulfonyl)-4-chlorobenzoyl]-1-piperazinecarboxylate | ethyl 4-[4-chloranyl-3-(phenylsulfamoyl)phenyl]carbonylpiperazine-1-carboxylate | ethyl 4-[4-chloro-3-(phenylsulfamoyl)benzoyl]piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H22ClN3O5S
Mol. Mass.:
451.924
SMILES:
CCOC(=O)N1CCN(CC1)C(=O)c1ccc(Cl)c(c1)S(=O)(=O)Nc1ccccc1
Structure:
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