Reaction Details Report a problem with these data
Target
Transcription factor p65
Ligand
BDBM43724
Substrate
n/a
Meas. Tech.
Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response
EC50
652±n/a nM
Citation
 PubChem, PC Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM43724
Synonyms:
(E)-1-(4-chlorophenyl)-3-(3-methoxyanilino)-2-propen-1-one | (E)-1-(4-chlorophenyl)-3-(3-methoxyanilino)prop-2-en-1-one | (E)-1-(4-chlorophenyl)-3-(m-anisidino)prop-2-en-1-one | (E)-1-(4-chlorophenyl)-3-[(3-methoxyphenyl)amino]prop-2-en-1-one | 1-(4-chlorophenyl)-3-[(3-methoxyphenyl)amino]-2-propen-1-one | MLS000686494 | SMR000268150 | cid_2267292
Type:
Small organic molecule
Emp. Form.:
C16H14ClNO2
Mol. Mass.:
287.741
SMILES:
COc1cccc(c1)N=CCC(=O)c1ccc(Cl)cc1 |w:8.8|
Structure:
Search PDB for entries with ligand similarity: