Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50008
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
400±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50008
Synonyms:
2-[[4-amino-5-[[4-(dimethylamino)anilino]-oxomethyl]-2-thiazolyl]thio]acetic acid ethyl ester | 2-[[4-amino-5-[[4-(dimethylamino)phenyl]carbamoyl]thiazol-2-yl]thio]acetic acid ethyl ester | MLS000079348 | SMR000036757 | cid_659614 | ethyl 2-[[4-amino-5-[[4-(dimethylamino)phenyl]carbamoyl]-1,3-thiazol-2-yl]sulfanyl]acetate | ethyl 2-[[4-azanyl-5-[[4-(dimethylamino)phenyl]carbamoyl]-1,3-thiazol-2-yl]sulfanyl]ethanoate
Type:
Small organic molecule
Emp. Form.:
C16H20N4O3S2
Mol. Mass.:
380.485
SMILES:
CCOC(=O)CSc1nc(N)c(s1)C(=O)Nc1ccc(cc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: