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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50028
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
433.417842±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50028
Synonyms:
4-[2-[2-[butyl(ethyl)amino]ethylamino]-3,4-diketo-cyclobuten-1-yl]piperazine-1-carboxylic acid ethyl ester | 4-[2-[2-[butyl(ethyl)amino]ethylamino]-3,4-dioxo-1-cyclobutenyl]-1-piperazinecarboxylic acid ethyl ester | MLS000093371 | SMR000028989 | cid_3235628 | ethyl 4-[2-({2-[butyl(ethyl)amino]ethyl}amino)-3,4-dioxocyclobut-1-en-1-yl]piperazine-1-carboxylate | ethyl 4-[2-[2-[butyl(ethyl)amino]ethylamino]-3,4-bis(oxidanylidene)cyclobuten-1-yl]piperazine-1-carboxylate | ethyl 4-[2-[2-[butyl(ethyl)amino]ethylamino]-3,4-dioxocyclobuten-1-yl]piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C19H32N4O4
Mol. Mass.:
380.4818
SMILES:
CCCCN(CC)CCNc1c(N2CCN(CC2)C(=O)OCC)c(=O)c1=O
Structure:
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