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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM37724
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
730.164095±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM37724
Synonyms:
(5Z)-5-{[4-(dimethylamino)phenyl]imino}-1,4-dimethyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile | 5-[4-(dimethylamino)phenyl]imino-1,4-dimethyl-2,6-bis(oxidanylidene)pyridine-3-carbonitrile | 5-[4-(dimethylamino)phenyl]imino-1,4-dimethyl-2,6-dioxo-3-pyridinecarbonitrile | 5-[4-(dimethylamino)phenyl]imino-1,4-dimethyl-2,6-dioxopyridine-3-carbonitrile | 5-[4-(dimethylamino)phenyl]imino-2,6-diketo-1,4-dimethyl-nicotinonitrile | MLS000089997 | SMR000024615 | cid_3241163
Type:
Small organic molecule
Emp. Form.:
C16H16N4O2
Mol. Mass.:
296.3238
SMILES:
CN(C)c1ccc(cc1)\N=C1/C(C)=C(C#N)C(=O)N(C)C1=O |t:13|
Structure:
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