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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50114
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
400±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50114
Synonyms:
4-(1-carbomethoxy-2,2,2-trifluoro-1-hydroxy-ethyl)-5-(dimethylaminomethyleneamino)furan-2-carboxylic acid ethyl ester | 5-(dimethylaminomethylideneamino)-4-(1,1,1-trifluoro-2-hydroxy-3-methoxy-3-oxopropan-2-yl)-2-furancarboxylic acid ethyl ester | MLS000568991 | SMR000150028 | cid_5179585 | ethyl 5-(dimethylaminomethylideneamino)-4-(1,1,1-trifluoro-2-hydroxy-3-methoxy-3-oxopropan-2-yl)furan-2-carboxylate | ethyl 5-(dimethylaminomethylideneamino)-4-[1,1,1-tris(fluoranyl)-3-methoxy-2-oxidanyl-3-oxidanylidene-propan-2-yl]furan-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H17F3N2O6
Mol. Mass.:
366.2898
SMILES:
CCOC(=O)c1cc(c(N=CN(C)C)o1)C(O)(C(=O)OC)C(F)(F)F |w:9.8|
Structure:
Search PDB for entries with ligand similarity: