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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM44498
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
1196.019543±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM44498
Synonyms:
2-Chloro-5-{5-[5-cyano-2-hydroxy-4-methyl-6-oxo-6H-pyridin-(3Z)-ylidenemethyl]-furan-2-yl}-benzoic acid allyl ester | 2-chloro-5-[5-[(Z)-(5-cyano-2,6-diketo-4-methyl-3-pyridylidene)methyl]-2-furyl]benzoic acid allyl ester | 2-chloro-5-[5-[(Z)-(5-cyano-4-methyl-2,6-dioxo-3-pyridinylidene)methyl]-2-furanyl]benzoic acid prop-2-enyl ester | MLS000528867 | SMR000121342 | cid_5769297 | prop-2-enyl 2-chloranyl-5-[5-[(Z)-[5-cyano-4-methyl-2,6-bis(oxidanylidene)pyridin-3-ylidene]methyl]furan-2-yl]benzoate | prop-2-enyl 2-chloro-5-[5-[(Z)-(5-cyano-4-methyl-2,6-dioxopyridin-3-ylidene)methyl]furan-2-yl]benzoate
Type:
Small organic molecule
Emp. Form.:
C22H15ClN2O5
Mol. Mass.:
422.818
SMILES:
CC1=C(C#N)C(=O)NC(=O)\C1=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OCC=C |c:1|
Structure:
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