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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50131
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
2283.99793±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50131
Synonyms:
3-Amino-6-furan-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid (2-fluoro-phenyl)-amide | 3-amino-N-(2-fluorophenyl)-6-(2-furanyl)-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-N-(2-fluorophenyl)-6-(2-furyl)thieno[2,3-b]pyridine-2-carboxamide | 3-amino-N-(2-fluorophenyl)-6-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-N-(2-fluorophenyl)-6-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide | MLS000559030 | SMR000149346 | cid_1959044
Type:
Small organic molecule
Emp. Form.:
C18H12FN3O2S
Mol. Mass.:
353.37
SMILES:
Nc1c(sc2nc(ccc12)-c1ccco1)C(=O)Nc1ccccc1F
Structure:
Search PDB for entries with ligand similarity: