Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50174
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
400±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50174
Synonyms:
1-[(Z)-(2-methyl-3-indolylidene)methyl]-2-(4-nitrophenyl)hydrazine | 1-[(Z)-(2-methylindol-3-ylidene)methyl]-2-(4-nitrophenyl)diazane | 1-[(Z)-(2-methylindol-3-ylidene)methyl]-2-(4-nitrophenyl)hydrazine | 2-methyl-1H-indole-3-carbaldehyde (4-nitrophenyl)hydrazone | MLS000575501 | SMR000184751 | cid_5337812
Type:
Small organic molecule
Emp. Form.:
C16H14N4O2
Mol. Mass.:
294.308
SMILES:
Cc1[n-]c2ccccc2c1C[NH+]=Nc1ccc(cc1)[N+]([O-])=O |w:11.12|
Structure:
Search PDB for entries with ligand similarity: