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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50194
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
400±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50194
Synonyms:
4-(4-Mercapto-8-methoxy-2-methyl-quinolin-3-yl)-butan-2-one | 4-(8-methoxy-2-methyl-4-sulfanylidene-1H-quinolin-3-yl)-2-butanone | 4-(8-methoxy-2-methyl-4-sulfanylidene-1H-quinolin-3-yl)butan-2-one | 4-(8-methoxy-2-methyl-4-thioxo-1H-quinolin-3-yl)butan-2-one | MLS000590395 | SMR000217406 | cid_868037
Type:
Small organic molecule
Emp. Form.:
C15H17NO2S
Mol. Mass.:
275.366
SMILES:
COc1cccc2c(S)c(CCC(C)=O)c(C)nc12
Structure:
Search PDB for entries with ligand similarity: