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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50213
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
5385.139464±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50213
Synonyms:
3-Hydroxy-naphthalene-2-carboxylic acid (1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazide | 3-hydroxy-N-[(Z)-[2-oxo-1-(phenylmethyl)-3-indolylidene]amino]-2-naphthalenecarboxamide | 3-oxidanyl-N-[(Z)-[2-oxidanylidene-1-(phenylmethyl)indol-3-ylidene]amino]naphthalene-2-carboxamide | MLS000553595 | N-[(Z)-(1-benzyl-2-keto-indolin-3-ylidene)amino]-3-hydroxy-2-naphthamide | N-[(Z)-(1-benzyl-2-oxoindol-3-ylidene)amino]-3-hydroxynaphthalene-2-carboxamide | SMR000171355 | cid_9591396
Type:
Small organic molecule
Emp. Form.:
C26H19N3O3
Mol. Mass.:
421.4474
SMILES:
Oc1cc2ccccc2cc1C(=O)N\N=C1/C(=O)N(Cc2ccccc2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: