Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50296
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
400±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50296
Synonyms:
2-[(4E)-2,5-diketo-4-[(5-methyl-2-furyl)methylene]imidazolidin-1-yl]-N-(m-tolyl)acetamide | 2-[(4E)-4-[(5-methyl-2-furanyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide | 2-[(4E)-4-[(5-methylfuran-2-yl)methylidene]-2,5-bis(oxidanylidene)imidazolidin-1-yl]-N-(3-methylphenyl)ethanamide | 2-[(4E)-4-[(5-methylfuran-2-yl)methylidene]-2,5-dioxoimidazolidin-1-yl]-N-(3-methylphenyl)acetamide | 2-{(4E)-4-[(5-methyl-2-furyl)methylene]-2,5-dioxoimidazolidin-1-yl}-N-(3-methylphenyl)acetamide | MLS000585416 | SMR000204179 | cid_15944782
Type:
Small organic molecule
Emp. Form.:
C18H17N3O4
Mol. Mass.:
339.3453
SMILES:
Cc1ccc(\C=C2\NC(=O)N(CC(=O)Nc3cccc(C)c3)C2=O)o1
Structure:
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