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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50532
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
400±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50532
Synonyms:
(6E)-4-nitro-6-[[(3-nitrophenyl)hydrazo]methylidene]-1-cyclohexa-2,4-dienone | (6E)-4-nitro-6-[[2-(3-nitrophenyl)hydrazinyl]methylidene]cyclohexa-2,4-dien-1-one | (6E)-4-nitro-6-[[N'-(3-nitrophenyl)hydrazino]methylene]cyclohexa-2,4-dien-1-one | 2-hydroxy-5-nitrobenzaldehyde (3-nitrophenyl)hydrazone | MLS000682108 | SMR000313511 | cid_5333005
Type:
Small organic molecule
Emp. Form.:
C13H10N4O5
Mol. Mass.:
302.2423
SMILES:
[O-][N+](=O)c1cccc(c1)N=[NH+]C[c-]1cc(ccc1=O)[N+]([O-])=O |w:9.9|
Structure:
Search PDB for entries with ligand similarity: