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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50538
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
6686.12805±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50538
Synonyms:
8,9-bis(oxidanyl)-[1]benzofuro[3,2-c]chromen-6-one | 8,9-dihydroxy-6-benzofuro[3,2-c][1]benzopyranone | 8,9-dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one | 8,9-dihydroxy-[1]benzofuro[3,2-c]chromen-6-one | 8,9-dihydroxybenzofuro[3,2-c]chromen-6-one | MLS000689780 | SMR000313384 | cid_638310
Type:
Small organic molecule
Emp. Form.:
C15H8O5
Mol. Mass.:
268.221
SMILES:
Oc1cc2oc3c(c2cc1O)c(=O)oc1ccccc31
Structure:
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