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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43368
Substrate
n/a
Meas. Tech.
E3 Ligase_Mutant_Dose Response
EC50
600±n/a nM
Citation
 PubChem, PC E3 Ligase_Mutant_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43368
Synonyms:
(1-acetamido-2,2,2-trichloroethyl) N,N-dimethylcarbamodithioate | Dimethyl-dithiocarbamic acid 1-acetylamino-2,2,2-trichloro-ethyl ester | MLS000554830 | N,N-dimethylcarbamodithioic acid (1-acetamido-2,2,2-trichloro-ethyl) ester | N,N-dimethylcarbamodithioic acid (1-acetamido-2,2,2-trichloroethyl) ester | SMR000146947 | [1-acetamido-2,2,2-tris(chloranyl)ethyl] N,N-dimethylcarbamodithioate | cid_3490047
Type:
Small organic molecule
Emp. Form.:
C7H11Cl3N2OS2
Mol. Mass.:
309.664
SMILES:
CN(C)C(=S)SC(NC(C)=O)C(Cl)(Cl)Cl
Structure:
Search PDB for entries with ligand similarity: