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Target
Mucolipin-3
Ligand
BDBM46795
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
29900±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46795
Synonyms:
1-tert-butylsulfonyl-N-(4-chloroanilino)methanimidoyl cyanide | 2-(tert-butylsulfonyl)-2-[2-(4-chlorophenyl)hydrazono]acetonitrile | 2-tert-butylsulfonyl-2-[(4-chlorophenyl)hydrazinylidene]acetonitrile | 2-tert-butylsulfonyl-2-[(4-chlorophenyl)hydrazinylidene]ethanenitrile | 2-tert-butylsulfonyl-2-[(4-chlorophenyl)hydrazono]acetonitrile | MLS000720846 | SMR000334201 | cid_4516212
Type:
Small organic molecule
Emp. Form.:
C12H14ClN3O2S
Mol. Mass.:
299.776
SMILES:
CC(C)(C)S(=O)(=O)C(=NNc1ccc(Cl)cc1)C#N |w:8.8|
Structure:
Search PDB for entries with ligand similarity: