Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46799
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
9970±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46799
Synonyms:
(5Z)-5-[[5-(diethylamino)-2-furanyl]methylidene]-3-propan-2-ylthiazolidine-2,4-dione | (5Z)-5-[[5-(diethylamino)-2-furyl]methylene]-3-isopropyl-thiazolidine-2,4-quinone | (5Z)-5-[[5-(diethylamino)furan-2-yl]methylidene]-3-propan-2-yl-1,3-thiazolidine-2,4-dione | 5-[1-(5-Diethylamino-furan-2-yl)-meth-(Z)-ylidene]-3-isopropyl-thiazolidine-2,4-dione | MLS000332786 | SMR000436128 | cid_1209895
Type:
Small organic molecule
Emp. Form.:
C15H20N2O3S
Mol. Mass.:
308.396
SMILES:
CCN(CC)c1ccc(\C=C2/SC(=O)N(C(C)C)C2=O)o1
Structure:
Search PDB for entries with ligand similarity: