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Target
Mucolipin-3
Ligand
BDBM46813
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
29900±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46813
Synonyms:
2-cyclopropyl-N-(3,4-dichloroanilino)-2-oxoethanimidoyl cyanide | 3-cyclopropyl-2-[(3,4-dichlorophenyl)hydrazinylidene]-3-oxidanylidene-propanenitrile | 3-cyclopropyl-2-[(3,4-dichlorophenyl)hydrazinylidene]-3-oxopropanenitrile | 3-cyclopropyl-2-[(3,4-dichlorophenyl)hydrazono]-3-keto-propionitrile | 3-cyclopropyl-2-[2-(3,4-dichlorophenyl)hydrazono]-3-oxopropanenitrile | MLS000859075 | SMR000459254 | cid_2818912
Type:
Small organic molecule
Emp. Form.:
C12H9Cl2N3O
Mol. Mass.:
282.125
SMILES:
Clc1ccc(NN=C(C#N)C(=O)C2CC2)cc1Cl |w:6.5|
Structure:
Search PDB for entries with ligand similarity: