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Target
Mitogen-activated protein kinase kinase kinase kinase 2
Ligand
BDBM51878
Substrate
n/a
Meas. Tech.
Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant
EC50
5140±n/a nM
Citation
 PubChem, PC Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant PubChem Bioassay (2009)[AID] 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 2
Synonyms:
2.7.11.1 | B lymphocyte serine/threonine-protein kinase | GC kinase | GCK | Germinal center kinase | M4K2_HUMAN | MAP4K2 | MAPK/ERK kinase kinase kinase 2 | MEK kinase kinase 2 | MEKKK 2 | RAB8IP | Rab8-interacting protein
Type:
n/a
Mol. Mass.:
91551.35
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
820
Sequence:
MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
  
Inhibitor
Name:
BDBM51878
Synonyms:
2,6-bis(iodanyl)-4-[2-(1,3,3-trimethylindol-2-ylidene)ethenyl]phenol | 2,6-diiodo-4-[2-(1,3,3-trimethyl-2-indolylidene)ethenyl]phenol | 2,6-diiodo-4-[2-(1,3,3-trimethylindol-2-ylidene)ethenyl]phenol | 2,6-diiodo-4-[2-(1,3,3-trimethylindolin-2-ylidene)vinyl]phenol | MLS000737639 | SMR000393809 | cid_233331
Type:
Small organic molecule
Emp. Form.:
C19H17I2NO
Mol. Mass.:
529.1533
SMILES:
CN1C(=C=Cc2cc(I)c(O)c(I)c2)C(C)(C)c2ccccc12 |(7.68,-1.39,;7.2,.08,;8.1,1.32,;9.64,1.32,;11.18,1.32,;11.95,-.02,;11.18,-1.35,;11.95,-2.69,;11.18,-4.02,;13.49,-2.69,;14.26,-4.02,;14.26,-1.35,;15.8,-1.35,;13.49,-.02,;7.2,2.55,;8.45,3.46,;6.73,4.02,;5.75,2.09,;4.41,2.86,;3.08,2.09,;3.08,.55,;4.41,-.22,;5.75,.55,)|
Structure:
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